Effect of glutamine replenishment. Received for publication February 2, Cell renewal in stomach, ileum, colon, and rectum. Pediatr Res ; There was no significant difference between the cell count and the DNA content of the monolayers grown with or without glutamine during the day period data not shown.
L-glutamine protects mucosal tissues, in addition to its role in promoting mucosal tissue repair [ 1011 ]. All authors approved the final version of the manuscript. The activity of mucosal glutamine synthetase is also extremely low Windmueller H G.
It is a component of the antioxidant glutathione synthesis and of the polyglutamated folic acid. Spilkervet, F. The 2. Burke, in ArchSurg, vol. Sibel Serin Kilicoglu or part without prior written approval are prohibited.
In all of these infants, PIVH occurred before any supplementation was administered. Pathological features of glutaminase toxicity.
Secondary endpoints included other variables of feeding tolerance, such as age when parenteral nutrition was discontinued, days of no enteral feeding, and the occurrence of Bell stage II or III necrotizing enterocolitis Intestinal permeability: This effect, together with the maintenance of cell growth, may play a key role in the prevention of intestinal mucosal atrophy.
A preferred method of treating gastro-intestinal dysfunctions includes providing apical glutamine for improving physiological functions. Glutamine is administered for preventing and treating gastro-intestinal dysfunctions and pathologic conditions. Shock ; Steenge, G. Weiss L. L-glutamine benefits Glutamine is one of the most common plasma amino acids, and its concentration often decreases post-operatively 11during sepsis 12 and after multiple trauma 13 or major burns 14similar to a fall in the concentrations of many other amino acids, electrolytes, minerals and trace elements; therefore, it seems prudent to give glutamine supplementation in all these conditions In the study by Vaughn et al 14glutamine was administered in water separately from the formula, whereas in both the study of Neu et al 12 and our study, glutamine was added to the formula.
Exp Mol Pathol. Xanthou M. Diet in the management of Crohn's disease. On the other hand, patients who experience metabolic stress because of the administration of anticancer agents develop L-glutamine deficiency, which may further promote injury to mucosal tissues [ 9 ].
The tissues are protected along the gastro-intestinal tract by blocking bacterial translocation with the glutamine. The sweet suspension proved to be very palatable to young children, but adolescents and adults sometimes found this formulation "too sweet. Preferably, the capsules are acid resistant slow-release release micro-capsules which last long enough to reach the requisite areas in the gastro-intestinal tract such as the intestines.
Glutamine replenishment for 18 hr causes a significant drop in bacterial translocation, that reaches base line level after 48 hr.
Fischer, J. Surg Forum ;ABSTRACT: Effect of Route of Glutamine Administration GM Mortality Following Experimental Enterocolitis, by D. J. Burke, 14th Clinical Congress Abstract Col.
14, No. 1, Supplement. “Reduction of the severity of Enterocolitis by Glutamine-Supplemented Enteral Diets” by Andrew D. Fox et al, in Surgical Form, Fox AD, Kripke SA, Paula JD et al. Effect of a glutamine-supplemented enteral diet on methotrexate induced enterocolitis.
J Parenter Enteral Nutr ; Klimberg VS, Souba WW, Dolsom DJ et al. Oral glutamine supports crypt cell turnover and accelerates intestinal. 8/1/ · Maximal effect was achieved with 8 mmol/L glutamine, which increased (P Cited by: Fox AD, Kripke SA, De Paula J, Berman JM, Settle RG, Rombeau JL.
Effect of a glutamine-supplemented enteral diet on methotrexate-induced enterocolitis.
JPEN J Parenter Enteral Nutr. Jul-Aug; 12 (4)– Souba WW, Klimberg VS, Hautamaki RD, Mendenhall WH, Bova FC, Howard RJ, Bland KI, Copeland EM. Glutamine(Gln) is considered a trophic factor for small intestinal epithelia, which is important during severe illness.
Its use in parenteral nutrition is precluded by its instability, a problem that may be overcome by use of the stable dipeptide l-alanyl-l-glutamine (Ala-Gln). The hypothesis was tested that Gln or Ala-Gln may stimulate cell proliferation not only in the ileum but also in Cited by: Glutamine (GLN) is commonly known as an important metabolite used for the growth of cancer cells but the effects of its intake in cancer patients are still not clear.
However, GLN is the main substrate for DNA and fatty acid synthesis. On the other hand, it reduces the oxidative stress by glutathione synthesis stimulation, stops the process of cancer cachexia, and nourishes the immunological Cited by: